The worm turns: publication bias and trial registers revisited

The worm turns on Helicobacter pylori.

How the Worm Turns, in Molecular Detail

Any behavior is, at its most elemental level, a coordinated series of muscle contractions. Those contractions are triggered by motor neurons, whose firing is controlled by other neurons, both excitatory and inhibitory, the whole chain set in motion by a stimulus. While the outlines of such a simple behavioral circuit have been understood for decades, the details— in particular, which neurotrans...

Tackling Publication Bias in Clinical Trial Reporting

X-ray diffraction analysis of 2b. Data was collected using a Bruker SMART CCD diffractometer with an Oxford low-temperature apparatus (193 K), using Mo Kα radiation and a graphite monochromator. A suitable crystal was chosen and mounted on a glass fiber using grease. Data were measured using omega scans of 0.3° per frame for 30 s, such that a hemisphere was collected. A total of 1271 frames wer...

Vocal registers revisited

The paper concerns the quest to find acoustical parameters that describe properties of vocal fold functioning from professional singing to voice pathologies. Improved data handling within the framework of phonetogram recordings has been used to arrive at a better understanding of what acoustical parameters could tell us about vocal registers.

Publication policy or publication bias?

Although ‘‘a large number of studies have appeared in the literature that report associations of low penetrance genetic variants with disease,’’ as suggested in the recent CEBP editorial (1), hardly any of these reports have been translated into solid results by replication studies, at least for the common cancers. To some extent this is inevitable, as false-positive associations are an inheren...